Microdosing
Protocols, clinical research, and practical guides for sub-perceptual dosing of psychedelics.
What Is Microdosing?
Microdosing means taking one-tenth to one-twentieth of a standard psychedelic dose — typically 0.1–0.3 g dried psilocybin mushroom or 5–20 micrograms of LSD — on a regular schedule. The aim is sub-perceptual: subtle shifts in mood and focus without altered perception. A self-blinding study by Szigeti et al. (2021) found improvements were statistically indistinguishable from placebo, making this one of the most debated practices in modern psychedelic science.
Microdosing
Microdosing Silicon Valley History: How Sub-Perceptual Doses Went from Fringe to Boardroom
Sub-perceptual psychedelic dosing and Silicon Valley share roots stretching back to the 1960s, when engineers at Menlo Park research labs first combined LSD…
Microdosing vs Macrodosing
Microdosing vs macrodosing is a comparison between two psychedelic dosing strategies that use the same substances at vastly different levels — microdosing…
Microdosing Myths and Misconceptions
Microdosing myths and misconceptions is a category of persistent misinformation that has grown alongside the practice itself.
Microdosing When Inadvisable
Microdosing when inadvisable is a harm-reduction framework that identifies the specific medical, psychiatric, pharmacological, and situational circumstances…
Microdosing Protocols Fadiman Stamets: Full Comparison Guide
A microdosing protocol is a structured schedule dictating dose days and rest days, designed to produce sub-perceptual cognitive shifts without tolerance buildup.
The Microdosing Placebo Debate: How to Tell If It's Actually Working
The microdosing placebo debate is a scientific and practical controversy that examines whether sub-perceptual doses of psilocybin or LSD produce genuine…
Origin of Microdosing Fadiman: How His Protocol Became the Standard
The origin of microdosing as a formalised practice traces to James Fadiman's 2011 book The Psychedelic Explorer's Guide, which introduced sub-perceptual…
Microdosing Research Current State
The current state of microdosing research reveals a field caught between enthusiastic self-reports and sobering controlled data.
Microdosing Medication Interactions
Microdosing medication interactions describe how sub-perceptual doses of psilocybin or LSD affect — or are affected by — prescribed drugs.
Microdosing Contraindications
A microdosing contraindication is a medical condition, psychiatric history, or concurrent medication that makes sub-perceptual psychedelic dosing inadvisable…
Microdosing Terminology Glossary
Microdosing has generated its own vocabulary — from Fadiman Protocol to volumetric dosing to sub-perceptual threshold.
Microdosing Surveys: What They Report
Microdosing surveys are large-scale questionnaires gathering self-reported data on why people microdose, perceived benefits, and adverse effects.
Microdosing Local Help Resources
A microdosing local help resource is a harm-reduction service, integration therapist, peer-support group, or clinical research programme near you that…
Microdosing Legal Status Europe: A Country-by-Country Breakdown
The microdosing legal status in Europe is a regulatory patchwork that varies dramatically from one country to the next, with no unified EU-wide framework…
Microdosing Harm Reduction Principles
Microdosing harm reduction is a structured set of practical guidelines that keeps sub-perceptual dosing of psychoactive substances safe and intentional.