Kanna
Kanna South Africa To West History
Kanna South Africa To West History is the ethnobotanical record of Sceletium tortuosum's journey from indigenous San and Khoekhoe use as a fermented chew to its first European documentation by Jan van Riebeeck in 1662 and its later pharmacological revival in the West.
More Kanna articles
Kanna Clinical Research
Published clinical research on Sceletium tortuosum is limited to a handful of small, short-term trials testing a specific standardised extract.
Kanna vs SSRIs
Kanna (Sceletium tortuosum) and SSRIs both increase serotonergic activity — kanna via mesembrine's proposed serotonin reuptake inhibition (Harvey et al.…
Kanna Safety and Side Effects
Kanna (Sceletium tortuosum) is a succulent plant with serotonergic activity that creates real interaction risks with common antidepressants and other…
Kanna Plant vs Extracts
Kanna plant vs extracts is a comparison that centres on one key variable: alkaloid concentration per gram.
How To Take Kanna
Kanna (Sceletium tortuosum) is a succulent plant that can be taken sublingually, orally, chewed, or insufflated — each route producing different onset times…
Kanna Dependency and Tolerance
Kanna (Sceletium tortuosum) does not appear to cause physical dependency based on limited clinical data, though tolerance may develop with sustained daily…
Fermentation Kanna
Fermentation is the traditional Khoisan method of processing Sceletium tortuosum into kougoed — bruising the fresh plant and allowing enzymatic breakdown…
Kanna and Other Substances
Combining kanna with other psychoactive substances carries real risks because its principal alkaloids have documented serotonergic activity (Harvey et al., 2011).
Kanna Contraindications
Kanna contraindications revolve around its serotonergic mechanism.
Kanna Dosage Guide
Dosing kanna correctly depends on whether you're working with dried plant material, fermented kougoed, or a concentrated extract — and on whether you…
Kanna and SSRIs
Kanna (Sceletium tortuosum) contains alkaloids with serotonin reuptake inhibitor activity, placing it in direct pharmacological overlap with SSRIs.
Kanna Effects
Kanna effects is a term describing the mood-lifting, anxiolytic, and mildly stimulating responses produced by Sceletium tortuosum, a succulent plant native…
Traditional San and Khoekhoe Use of Kanna
The San and Khoekhoe peoples of southern Africa harvested, fermented, and chewed Sceletium tortuosum — called kougoed — for centuries before European contact.